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J Am Coll Nutr. 2015;34(6):470-7. doi: 10.1080/07315724.2014.1003999. Epub 2015 Jun 1.

Acute Effects of a Spinach Extract Rich in Thylakoids on Satiety: A Randomized Controlled Crossover Trial.

Author information

1
a Pennington Biomedical Research Center.
2
b School of Nutrition and Food Sciences, Louisiana State University System , Baton Rouge , Louisiana ;
3
c Louisiana State University School of Medicine , New Orleans , Louisiana ;
4
d Greenleaf Medical AB , Stockholm , SWEDEN ;
5
e Department of Experimental Medical Science, Appetite Regulation Unit, Faculty of Medicine, Lund University , Lund , SWEDEN.

Abstract

OBJECTIVE:

By retarding fat digestion, thylakoids, the internal photosynthetic membrane system of green plants, promote the release of satiety hormones. This study examined the effect of consuming a single dose of concentrated extract of thylakoids from spinach on satiety, food intake, lipids, and glucose compared to a placebo.

DESIGN:

Sixty overweight and obese individuals enrolled in a double-blind randomized crossover study consumed the spinach extract or placebo in random order at least a week apart. Blood was drawn for assessments of lipids and glucose before a standard breakfast meal, followed 4 hours later by a 5 g dose of the extract and a standard lunch. Visual analog scales were administered before lunch and at intervals until an ad libitum pizza dinner served 4 hours later. Two hours after lunch a second blood draw was conducted. Mixed models were used to analyze response changes.

RESULTS:

Compared to placebo, consuming the spinach extract reduced hunger (p < 0.01) and longing for food over 2 hours (p < 0.01) and increased postprandial plasma glucose concentrations (p < 0.01). There were no differences in plasma lipids and energy intake at dinner, but males showed a trend toward decreased energy intake (p = 0.08).

CONCLUSIONS:

At this dose, the spinach extract containing thylakoids increases satiety over a 2-hour period compared to a placebo. Thylakoid consumption may influence gender-specific food cravings.

KEYWORDS:

fat digestion; food cravings; satiety; spinach; thylakoids

PMID:
26029978
PMCID:
PMC4600649
DOI:
10.1080/07315724.2014.1003999
[Indexed for MEDLINE]
Free PMC Article

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