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J Gastrointest Oncol. 2015 Jun;6(3):329-35. doi: 10.3978/j.issn.2078-6891.2015.012.

Irreversible electroporation of locally advanced pancreatic neck/body adenocarcinoma.

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1
Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KY, USA.

Abstract

OBJECTIVE:

Irreversible electroporation (IRE) of locally advanced pancreatic adenocarcinoma of the neck has been used to palliate appropriate stage 3 pancreatic cancers without evidence of metastasis and who have undergone appropriate induction therapy. Currently there has not been a standardized reported technique for pancreatic mid-body tumors for patient selection and intra-operative technique.

PATIENTS:

Subjects are patients with locally advanced pancreatic adenocarcinoma of the body/neck who have undergone appropriate induction chemotherapy for a reasonable duration.

MAIN OUTCOME MEASURES:

Technique of open IRE of locally advanced pancreatic adenocarcinoma of the neck/body is described, with the emphasis on intra-operative ultrasound and intra-operative electroporation management.

RESULTS:

The technique of open IRE of the pancreatic neck/body with bracketing of the celiac axis and superior mesenteric artery with continuous intraoperative ultrasound imaging and consideration of intraoperative navigational system is described.

CONCLUSIONS:

IRE of locally advanced pancreatic adenocarcinoma of the body/neck is feasible for appropriate patients with locally advanced unresectable pancreatic cancer.

KEYWORDS:

Pancreatic neck/body; irreversible electroporation (IRE); locally advanced pancreatic cancer; palliation

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