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Int J Gynaecol Obstet. 2015 Aug;130(2):116-22. doi: 10.1016/j.ijgo.2015.03.033. Epub 2015 May 14.

A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy.

Author information

1
Center for Health Management, School of Health Services Management, Anhui Medical University, Hefei, China.
2
Department of Nutrition, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing, China.
3
Department of Social Medicine and Health Services Management, School of Public Health, Kunming Medical University, Kunming, China.
4
Second Affiliated Hospital of Anhui Medical University, Hefei, China.
5
Department of Rehabilitation Medicine, The Affiliated Provincial Hospital of Anhui Medical University, Hefei, China.
6
Center for Health Management, School of Health Services Management, Anhui Medical University, Hefei, China. Electronic address: xinchangmao@ahmu.edu.cn.

Abstract

BACKGROUND:

Previous reports of the relationship between pregnancy loss and caffeine/coffee consumption have been inconsistent.

OBJECTIVES:

To evaluate the association between pregnancy loss and caffeine and coffee consumption.

SEARCH STRATEGY:

PubMed was searched for reports published before September 2014, with the keywords "caffeine," "coffee," "beverage," "miscarriage," "spontaneous abortion," and "fetal loss."

SELECTION CRITERIA:

Case-control and cohort studies were included when they had been reported in English, the exposure of interest was caffeine/coffee consumption during pregnancy, the outcome of interest was spontaneous abortion or fetal death, and multivariate-adjusted odds ratios (ORs) or risk ratios were provided or could be calculated.

DATA COLLECTION AND ANALYSIS:

Data were extracted and combined ORs calculated.

MAIN RESULTS:

Overall, 26 studies were included (20 of caffeine and eight of coffee). After adjustment for heterogeneity, caffeine consumption was associated with an increased risk of pregnancy loss (OR 1.32, 95% confidence interval [CI] 1.24-1.40), as was coffee consumption (OR 1.11, 95% CI 1.02-1.21). A dose-response analysis suggested that risk of pregnancy loss rose by 19% for every increase in caffeine intake of 150 mg/day and by 8% for every increase in coffee intake of two cups per day.

CONCLUSIONS:

Consumption of caffeine and coffee during pregnancy seems to increase the risk of pregnancy loss.

KEYWORDS:

Caffeine; Coffee; Fetal death; Meta-analysis; Pregnancy loss; Spontaneous abortion

PMID:
26026343
DOI:
10.1016/j.ijgo.2015.03.033
[Indexed for MEDLINE]

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