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Nutr Metab Cardiovasc Dis. 2015 Aug;25(8):714-23. doi: 10.1016/j.numecd.2015.04.008. Epub 2015 Apr 29.

Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects.

Author information

1
Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China. Electronic address: Metro1168@hotmail.com.
2
Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.
3
Department of Cardiac Surgery, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.

Abstract

BACKGROUND & AIMS:

A growing body of evidence suggests that beta-glucan derived from oats or barley can reduce cardiovascular disease risk through reductions in serum lipids. However, the effects of beta-glucan on lipid changes in hypercholesterolemic patient groups are inconsistent. The objective of this study was to identify and quantify the effect of beta-glucan, a marker of water-soluble fiber, on various lipid parameters and glucose level in hypercholesterolemic subjects.

METHODS AND RESULTS:

We performed a comprehensive literature search to identify the relevant randomized controlled trials (RCTs) that investigated the effects of beta-glucan consumption in hypercholesterolemic subjects. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses were also performed. Seventeen eligible RCTs with 916 subjects were included in the meta-analysis. The pooled result showed that beta-glucan consumption in hypercholesterolemic population significantly lowered the total cholesterol (TC) (MD, -0.26 mmol/L; 95% CI, -0.33 to -0.18; P < 0.00001) and low-density lipoprotein (LDL)-cholesterol concentration (MD, -0.21 mmol/L; 95% CI, -0.27 to -0.14; P < 0.00001). However, there were no significant differences in high-density lipoprotein (HDL)-cholesterol, triglycerides (TG) and glucose. No adverse effects were reported among the eligible trials.

CONCLUSION:

Our meta-analysis showed that beta-glucan consumption significantly decreased TC and LDL-cholesterol concentrations but did not affect TG, HDL-cholesterol, and glucose concentrations in hypercholesterolemic subjects.

KEYWORDS:

Beta-glucan; Dietary fiber; Hypercholesterolemic; Meta-analysis; Serum lipids

PMID:
26026211
DOI:
10.1016/j.numecd.2015.04.008
[Indexed for MEDLINE]

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