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J Immunol. 2015 Jul 1;195(1):36-40. doi: 10.4049/jimmunol.1500366. Epub 2015 May 29.

Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells.

Author information

1
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and.
2
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and.
3
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and Howard Hughes Medical Institute, Dallas, TX 75390.
4
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and felix_yarovinsky@URMC.Rochester.edu.

Abstract

Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-γ production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-γ upon neutrophil activation, the first step during responses to many microbial infections.

PMID:
26026057
PMCID:
PMC4557207
DOI:
10.4049/jimmunol.1500366
[Indexed for MEDLINE]
Free PMC Article

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