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Lancet. 2015 Sep 5;386(9997):983-94. doi: 10.1016/S0140-6736(14)61909-7. Epub 2015 May 27.

Psoriasis.

Author information

1
Department of Dermatology and Venereology, Geneva University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. Electronic address: wolf-henning.boehncke@hcuge.ch.
2
Department of Dermatology, Venereology and Allergology, University Medical Center, Georg August University, Göttingen, Germany. Electronic address: michael.schoen@med.uni-goettingen.de.

Abstract

Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity. Understanding the role of immune function in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin. In this Seminar, we highlight the clinical diversity of psoriasis and associated comorbid diseases. We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis.

PMID:
26025581
DOI:
10.1016/S0140-6736(14)61909-7
[Indexed for MEDLINE]

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