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Aging Clin Exp Res. 2016 Feb;28(1):165-6. doi: 10.1007/s40520-015-0381-9. Epub 2015 May 30.

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials.

Author information

  • 1Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • 2Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China. zhenyutang0791@163.com.

Abstract

Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly.

KEYWORDS:

Cognitive decline; Meta-analysis; Omega-3 fatty acids; Randomized controlled trial

PMID:
26025463
DOI:
10.1007/s40520-015-0381-9
[PubMed - indexed for MEDLINE]
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