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Expert Rev Anti Infect Ther. 2015 Jul;13(7):883-96. doi: 10.1586/14787210.2015.1040765. Epub 2015 May 29.

Antibiotic resistance to Propionobacterium acnes: worldwide scenario, diagnosis and management.

Author information

1
Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Abstract

Antibiotic resistance in cutaneous Propionobacterium is a global problem. As a general rule, resistance levels are high to macrolides, trimethoprim/sulfamethoxazole and clindamycin, while tetracyclines and levofloxacin have low resistance potential. Newer preparations like doxycycline MR and doxycycline 20 mg are subantimicrobial and may not lead to resistance. Sampling techniques are crucial to determine resistance. Genomic evaluation using 16S ribosomal RNA gene sequencing can be useful in diagnosing mutations and mapping phylotypes of Propionobacterium acnes. Resistance may lead to slow response and relapses. Apart from benzoyl peroxide, azelaic acid, topical dapsone, oral zinc and retinoids, novel molecules with little resistance potential include octadecenedioic acid, phytosphingosine, lauric acid, retapamulin, resveratrol, T-3912 and NB-003. The use of oral retinoids and non-antibiotics like zinc can prevent resistance and help reduce the dependence on antibiotics.

KEYWORDS:

16S RNA PCR; BPO; NB-003; T-3912; acne; azelaic acid; biofilms; clindamycin; lauric acid; levofloxacin; macrolides; resistance; resveratrol; retapamulin

PMID:
26025191
DOI:
10.1586/14787210.2015.1040765
[Indexed for MEDLINE]

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