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Nutr Rev. 2015 Mar;73(3):175-90. doi: 10.1093/nutrit/nuu007. Epub 2015 Feb 13.

Main characteristics of metabolically obese normal weight and metabolically healthy obese phenotypes.

Author information

1
TFS Teixeira, RDM Alves, APB Moreira, and MdCG Peluzio are with the Nutrition and Health Department, Federal University of Viçosa, Viçosa, MG, Brazil. tatiana.salles@ufv.br tatifichee@hotmail.com.
2
TFS Teixeira, RDM Alves, APB Moreira, and MdCG Peluzio are with the Nutrition and Health Department, Federal University of Viçosa, Viçosa, MG, Brazil.

Abstract

In this review, the influence of fat depots on insulin resistance and the main characteristics of metabolically obese normal-weight and metabolically healthy obese phenotypes are discussed. Medline/PubMed and Science Direct were searched for articles related to the terms metabolically healthy obesity, metabolically obese normal weight, adipose tissue, and insulin resistance. Normal weight and obesity might be heterogeneous in regard to their effects. Fat distribution and lower insulin sensitivity are the main factors defining phenotypes within the same body mass index. Although these terms are interesting, controversies about them remain. Future studies exploring these phenotypes will help elucidate the roles of adiposity and/or insulin resistance in the development of metabolic alterations.

KEYWORDS:

adiposity; insulin resistance; obesity

PMID:
26024540
DOI:
10.1093/nutrit/nuu007
[Indexed for MEDLINE]

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