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Kidney Int. 2015 Jun;87(6):1089-91. doi: 10.1038/ki.2015.80.

The vascular secret of Klotho.

Author information

1
1] Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark [2] Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
2
Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Abstract

Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise uniquely from its presence in the circulation.

PMID:
26024025
DOI:
10.1038/ki.2015.80
[Indexed for MEDLINE]

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