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Molecules. 2015 May 27;20(6):9745-66. doi: 10.3390/molecules20069745.

Molecular Interactions of β-(1→3)-Glucans with Their Receptors.

Author information

1
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. laurent.legentil@ensc-rennes.fr.
2
Université européenne de Bretagne, F-35000 Rennes, France. laurent.legentil@ensc-rennes.fr.
3
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. franck.paris@ensc-rennes.fr.
4
Université européenne de Bretagne, F-35000 Rennes, France. franck.paris@ensc-rennes.fr.
5
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. caroline.ballet@ensc-rennes.fr.
6
Université européenne de Bretagne, F-35000 Rennes, France. caroline.ballet@ensc-rennes.fr.
7
INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. sophie.trouvelot@u-bourgogne.fr.
8
INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. xavier.daire@dijon-inra.fr.
9
Department of Pathology, University of Louisville, Louisville, KY 40202, USA. vaclav.vetvicka@louisville.edu.
10
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. vincent.ferrieres@ensc-rennes.fr.
11
Université européenne de Bretagne, F-35000 Rennes, France. vincent.ferrieres@ensc-rennes.fr.

Abstract

β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(1→3)-glucans can trigger different immune responses and act as efficient immunostimulating agents. They constitute prevalent sources of carbons for microorganisms after subsequent recognition by digesting enzymes. Nevertheless, mechanisms associated with both roles are not yet clearly understood. This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.

KEYWORDS:

CBM; CR3; Dectin-1; glycolipids; langerin; β-(1→3)-glucans

PMID:
26023937
PMCID:
PMC6272582
DOI:
10.3390/molecules20069745
[Indexed for MEDLINE]
Free PMC Article

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