Development of an injection molded ethylene-vinyl acetate copolymer (EVA) intravaginal insert for the delivery of progesterone to cattle

A J Cappadoro; J A Luna

doi:10.1016/j.anireprosci.2015.05.007

Development of an injection molded ethylene-vinyl acetate copolymer (EVA) intravaginal insert for the delivery of progesterone to cattle

Anim Reprod Sci. 2015 Jul:158:104-8. doi: 10.1016/j.anireprosci.2015.05.007. Epub 2015 May 19.

Authors

A J Cappadoro¹, J A Luna²

Affiliations

¹ Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Predio CCT-CONICET Santa Fe, Ruta Nacional 168, Km 1, 3000 Santa Fe, Argentina. Electronic address: alecappadoro@gmail.com.
² Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Predio CCT-CONICET Santa Fe, Ruta Nacional 168, Km 1, 3000 Santa Fe, Argentina.

PMID: 26022232
DOI: 10.1016/j.anireprosci.2015.05.007

Abstract

The purpose of this study was to develop a new injection-molded intravaginal insert manufactured from ethylene-vinyl acetate containing progesterone for a 7-day insertion period in cattle. The manufacturing process resulted in a reduction in the residual drug compared to the silicone insert available while still maintaining biological performance.

Keywords: Controlled release; Estrous control; Ethylene-vinyl acetate; Intravaginal drug delivery; Progesterone delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Intravaginal
Animals
Cattle / physiology*
Drug Delivery Systems / instrumentation*
Drug Delivery Systems / methods
Female
Polyvinyls / chemistry*
Progesterone / administration & dosage*
Technology, Pharmaceutical / methods*

Substances

Polyvinyls
ethylenevinylacetate copolymer
Progesterone