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AJNR Am J Neuroradiol. 2015 Sep;36(9):1786-90. doi: 10.3174/ajnr.A4332. Epub 2015 May 28.

Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling.

Author information

1
From the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.) U1000 (V.D.-R., D.G., R.C., F.B., N.B.) vdangouloffros@yahoo.fr.
2
From the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.) University René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France U1000 (V.D.-R., D.G., R.C., F.B., N.B.) Inserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France.
3
University René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France Department of Neuropathology (M.P., P.V.), Centre Hospitalier Sainte Anne, Paris, France.
4
Pediatric Neurosurgery (T.B., S.P., C.S.-R.) University René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France.
5
Clinical Research Unit (C.E.), Hôpital Necker-Enfants Malades, Assistance-Publique Hôpitaux de Paris, Paris, France.
6
From the Departments of Pediatric Radiology (V.D.-R., D.G., R.C., F.B., N.B.) University René Descartes (D.G., M.P., T.B., R.C., S.P., C.S.-R., F.B., P.V., N.B.), Pôle de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France U1000 (V.D.-R., D.G., R.C., F.B., N.B.) U781 (N.B.), Institut national de la santé et de la recherche médicale, Paris, France Inserm UMR1163 - Institut Imagine (D.G., R.C., F.B., N.B.), Université Paris Descartes-Sarbonne Paris Cité, Paris, France.

Abstract

Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which are difficult to distinguish with conventional imaging. We aimed to analyze the diagnostic accuracy of PWI, by using both pseudocontinuous arterial spin-labeling and DSC-PWI. We reviewed the PWI of 13 children with choroid plexus neoplasms (7 papillomas and 6 carcinomas). We quantified CBF, relative CBF, and relative CBV in each lesion and compared papillomas and carcinomas. Relative CBF values by using arterial spin-labeling were significantly higher for carcinomas (P = .028). The median value of relative CBF was 1.7 (range, 1.4-1.9) for carcinomas and 0.4 (range, 0.3-0.6) for papillomas. The CBF median value was 115 mL/min/100 g (range, 90-140 mL/min/100 g) for carcinomas and 41 mL/min/100 g (range, 10-73 mL/min/100 g) for papillomas (P = .056). Measures with DSC-PWI were more variable and not significantly different (P = .393). Arterial spin-labeling is a promising technique to differentiate choroid plexus carcinomas and papillomas.

PMID:
26021621
DOI:
10.3174/ajnr.A4332
[Indexed for MEDLINE]
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