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Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 1:S74-9.

[Effect of pravastatine plus ezetimibe on carotid intima media thickness in patients with lupus erythematosus].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Departamento de Medicina Interna, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal. olgavera62@yahoo.com.mx.

Abstract

in English, Spanish

BACKGROUND:

Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis that can be assessed by the carotid intima media thickness (CIMT) measurement. A prompt hypolipidemic treatment should be a part of the integral management. The aim of this study is to determine the effect of therapy with pravastatin plus ezetimibe on the CIMT in SLE patients.

METHODS:

Longitudinal, prospective, quasi-experimental trial. Out of 60 SLE patients in whom a carotid ultrasound was performed, we chose 22 with a CIMT>0.7 mm who were administered pravastatin plus ezetimibe during 6 months with determination of CIMT at the end of the study. We performed the following tests: total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, tryglicerides, C-reactive protein (CRP), liver function, muscle enzimes and glucose, basal and at the end of treatment.

STATISTICAL ANALYSIS:

descriptive statistics and Wilcoxon test were used.

RESULTS:

There were 22 women with an age of 42±6.3 years, average disease evolution 7.5±6.6 years, of whom, 18 concluded the study. Right basal CIMT was 0.829±0.1448 vs. final 0.688±0.1453, p<0.003; left CIMT was 0.820±0.1312 vs. 0.724±0.1348, p<0.004. TC 208 mg/dl vs 168 mg/dl, LDL-C 125 mg/dl vs. 72 mg/dl, p=0.0004. CRP 3.12 vs. 2.25 p=0.004. In 2 cases there were gastrointestinal, skin and muscle adverse effects.

CONCLUSIONS:

Treatment with pravastatin plus ezetimibe decreases the CIMT with improvement in the concentration of total cholesterol, LDL-C and CRP levels with good toleration.

KEYWORDS:

Atherosclerosis; Ezetimibe; Intima media thickness; Pravastatin; Systemic lupus erythematosus

PMID:
26020669
[Indexed for MEDLINE]

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