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World J Gastroenterol. 2015 May 21;21(19):6026-31. doi: 10.3748/wjg.v21.i19.6026.

Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review.

Author information

1
Salman Yousuf Guraya, College of Medicine, Taibah University, Almadinah Almunawwarah 41477, Saudi Arabia.

Abstract

AIM:

To provide a quantitative assessment of the association between type 2 diabetes mellitus (T2DM) and the risk of colorectal cancer (CRC).

METHODS:

Systematic review was conducted thorough MEDLINE, EMBASE, Cochrane Library, and ISI Web of knowledge databases till 31(st) January 2014. This meta-analysis included the cohort studies that illustrated relative risk (RR) or odds ratio estimates with 95%CI for the predictive risk of CRC by T2DM. Summary relative risks with 95%CI were analyzed by using an effects summary ratio model. Heterogeneity among studies was assessed by the Cochran's Q and I (2) statistics.

RESULTS:

The meta analysis of 8 finally selected studies showed a positive correlation of T2DM with the risk of CRC as depicted by effects summary RR of 1.21 (95%CI: 1.02-1.42). Diabetic women showed greater risk of developing CRC as their effect summary RR of 1.22 (95%CI: 1.01-49) with significant overall Z test at 5% level of significance was higher than the effect summary RR of 1.17 (95%CI: 1.00-1.37) of men showing insignificant Z test. The effect summary RR of 1.19 with 95%CI of 1.07-1.33 indicate a positive relationship between DM and increased risk of CRC with significant heterogeneity (I (2) = 92% and P-value < 0.05).

CONCLUSION:

Results from this systematic review and meta-analysis report that diabetic people have an increased risk of CRC as compared to non-diabetics.

KEYWORDS:

Cancer statistics; Colorectal cancer; Gastrointestinal cancers; Risk ratio; Type 2 diabetes mellitus

PMID:
26019469
PMCID:
PMC4438039
DOI:
10.3748/wjg.v21.i19.6026
[Indexed for MEDLINE]
Free PMC Article

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