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Acta Diabetol. 2015 Dec;52(6):1077-81. doi: 10.1007/s00592-015-0772-6. Epub 2015 May 28.

Vitamin D levels at birth and risk of type 1 diabetes in childhood: a case-control study.

Author information

1
Department of Health Sciences, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
2
IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy.
3
Department of Pediatrics, Newborn Screening Regional Center, University of Torino, Turin, Italy.
4
Department of Pediatrics, University of Turin, Turin, Italy.
5
Pediatric Hospital, Tortona, Italy.
6
Saint Arrigo Pediatric Hospital, Alessandria, Italy.
7
Pediatrics Hospital, Cuneo, Italy.
8
Pediatrics Hospital, Vercelli, Italy.
9
Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
10
Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy. graziella.bruno@unito.it.

Abstract

AIMS:

To assess whether vitamin D levels at birth were associated with risk of having type 1 diabetes up to 10 years of age and the potential modifier effect of ethnic group.

METHODS:

The Piedmont Diabetes Registry and the Newborn Screening Regional data were linked to identify cases (n = 67 incident children aged ≤10 years at diabetes onset, 2002-2012) and up to five controls (n = 236) matched for birthday and ethnic group. Cards with neonatal blood spot were used and 25-hydroxyvitamin D(3) assessed with tandem mass spectroscopy.

RESULTS:

In conditional logistic regression, OR for unit increment of log vitamin D was 0.78 (95 % CI 0.56-1.10). Vitamin D was significantly lower in migrant than in Italian control newborn babies (p < 0.0001), and interaction between vitamin D and migrant status was statistically significant (p = 0.04). Compared to migrant newborns babies with vitamin D ≥ 2.14 ng/ml, migrants with lower levels had an OR of 14.02 (1.76-111.70), whereas no association was evident in Italians.

CONCLUSIONS:

Our case-control study within the Piedmont Diabetes Registry showed no association between vitamin D levels at birth and risk of having type 1 diabetes up to 10 years of age, apart from the subgroup of migrant babies, which might have clinical implications if confirmed.

KEYWORDS:

Epidemiology; Incidence; Migrants

PMID:
26018939
DOI:
10.1007/s00592-015-0772-6
[Indexed for MEDLINE]

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