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Clin Nucl Med. 2015 Jul;40(7):e363-5. doi: 10.1097/RLU.0000000000000816.

Somatostatin Receptors in an Anaplastic Oligodendroglioma Relapse Evidenced By 68Ga DOTANOC PET/CT.

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From the *Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; and †Department of Nuclear Medicine, SS. Antonio e Biagio e C. Arrigo City Hospital, Alessandria Italy.


Six years ago, a right frontal lobe anaplastic oligodendroglioma negative for AE1/AE3 and HBM-45, positive for 1p/19q deletion, EMA, GFAP, and synaptophysin was excised from a 50-year-old woman. Treatments that followed were radiation therapy, and surgery plus radiation therapy and temozolomide for a relapse with an early partial response, followed by disease progression. In the middle of last year, ⁶⁸Ga-DOTANOC PET/CT was carried out to evaluate the possibility of treatment with peptide receptor radionuclide therapy. The examination revealed a grossly round-shaped uptake corresponding to the surgical wall, with some smaller uptakes disseminated in different parts of the brain.

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