Format

Send to

Choose Destination
J Med Virol. 2015 Dec;87(12):2021-6. doi: 10.1002/jmv.24279. Epub 2015 Jun 12.

Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study.

Author information

1
Department of Medicine, University of Washington, Seattle, Washington.
2
Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington.
3
Department of Pharmacy, University of Washington, Seattle, Washington.
4
Department of Laboratory Medicine, University of Washington, Seattle, Washington.

Abstract

Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differences in laboratory testing time and antiviral use among a subset of 175 consecutive adult inpatients tested for influenza in two respiratory seasons before and after implementation of rapid PCR-based influenza testing at an academic medical center. Of the 350 hospitalized inpatients included in this analysis, 96 (27%) were over 65 years of age and 308 (88%) had a comorbid condition. The overall time to result decreased significantly from 25.2 to 1.7 hr (P < 0.001) after implementation of rapid PCR-based influenza testing. Among influenza-negative patients, the frequency of oseltamivir initiation remained unchanged (before: 43% vs. after: 45%; P = 0.60), though the median duration of oseltamivir was significantly decreased from 1.1 to 0.0 days (P < 0.001). By providing an earlier result to clinicians, rapid PCR-based influenza tests may decrease unnecessary antiviral use among adult inpatients who test negative for influenza.

KEYWORDS:

PCR; infection control; influenza; oseltamivir

PMID:
26017150
PMCID:
PMC4594176
DOI:
10.1002/jmv.24279
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center