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Acta Cir Bras. 2015 May;30(5):313-8. doi: 10.1590/S0102-865020150050000002.

Study of renal and hepatic toxicity in rats supplemented with creatine.

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Medical School of Itajuba, Brazil.
FMIt, Itajuba, MG, Brazil.



To evaluate the renal and hepatic function, through biochemical analysis after 14 days of creatine supplementation in physically inactive rats.


Twenty four male, adult, Wistar rats were used which were kept in individual metabolic cages and were distributed into four groups, and received the following treatments by gavage:1) CONTROL: distilled water; 2)Creatine 0.5g/Kg/day; 3) Creatine 1g/Kg/day; 4) Creatine 2g/Kg/day. Their urinary outputs as well as food and water intake were daily measured. At the end of the experiment, the animals were euthanized and serum samples were stored for biochemical analysis.


Creatine supplementation at the doses given produced no significant changes in plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, glucose, creatinine, urea, and creatinine clearance, compared to control group (p> 0.05) Similarly, water and food intake, as well as urinary output, did not show significant changes among the four groups studied.


At the doses used, oral creatine supplementation did not result in renal and/or hepatic toxicity.

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