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Clin Microbiol Rev. 2015 Jul;28(3):603-61. doi: 10.1128/CMR.00134-14.

Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.

Author information

1
Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia Steven.Tong@menzies.edu.au vance.fowler@duke.edu.
2
Global and Tropical Health, Menzies School of Health Research, Darwin, Northern Territory, Australia.
3
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
4
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA Steven.Tong@menzies.edu.au vance.fowler@duke.edu.

Abstract

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

PMID:
26016486
PMCID:
PMC4451395
DOI:
10.1128/CMR.00134-14
[Indexed for MEDLINE]
Free PMC Article

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