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Life Sci. 1989;45(24):2373-80.

Lactobionic acid as an iron chelator: a rationale for its effectiveness as an organ preservant.

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1
Department of Medicine, University of Pittsburgh, PA 15261.

Abstract

Lactobionic acid, a major constituent of a solution used to preserve organs prior to transplantation, can chelate ferric iron. This is evident by its ability to solubilize iron as well as changes that occur in the UV-VIS spectra of iron in its presence. Relative to iron (III) chelated to EDTA, the lactobionic acid-iron (III) complex is less able to participate in the Fenton reaction as measured by formaldehyde generation from DMSO and bleaching of p-N,N-dimethylnitrosoaniline. Similar effects are seen with citrate and ATP, two substances which also appear to be able to ameliorate ischemia/reperfusion injury. These findings present a rationale for the effectiveness of lactobionic acid as an organ preservant.

PMID:
2601586
[Indexed for MEDLINE]

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