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J Endocrinol Invest. 2015 Nov;38(11):1183-9. doi: 10.1007/s40618-015-0304-9. Epub 2015 May 27.

Effects of a high-protein/low-carbohydrate versus a standard hypocaloric diet on adipocytokine levels and cardiovascular risk factors during 9 months, role of rs6923761 gene variant of glucagon-like peptide 1 receptor.

Author information

1
Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain. dadluis@yahoo.es.
2
Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain.

Abstract

BACKGROUND:

The role of GLP-1 R variants on body weight response after dietary intervention is unclear.

OBJECTIVE:

The aim was to investigate the role of this polymorphism on cardiovascular risk factors, adipokine levels and weight loss secondary to a high-protein/low-carbohydrate vs. standard hypocaloric diets during 9 months.

DESIGN:

211 obese subjects were randomly allocated to one of these two diets for a period of 9 months; diet HP (high protein/low carbohydrate) and diet S (standard).

RESULTS:

Ninety-four patients (44.5%) had the genotype GG (wild group) and 117 (55.5%) patients had the next genotypes; GA (89 patients, 42.2%) or AA (28 patients, 13.3%) (mutant group). With both diets and in both genotype groups, body mass index, weight, fat mass, waist circumference and systolic blood pressure decreased. Anthropometric parameters were higher in non-A allele carriers than A allele carriers. With diet HP in both genotypes, LDL cholesterol, total cholesterol, leptin, insulin levels and HOMA-R decreased. With the diet S and only in wild genotype, the same parameters decreased, too.

CONCLUSION:

Our data showed a lack of association of rs6923761 GLP-1 R polymorphism with weight loss. Better anthropometric parameters in obese subjects with the mutant allele (A) of rs6923761 GLP-1 R polymorphism were observed. Total cholesterol, LDL cholesterol, insulin levels and HOMA-R decreased in all patients with both diets, although A allele carriers treated with standard diet did not show these changes.

KEYWORDS:

Glucagon-like peptide 1 receptor; Hypocaloric diet; Weight loss; rs6923761

PMID:
26015316
DOI:
10.1007/s40618-015-0304-9
[Indexed for MEDLINE]

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