Format

Send to

Choose Destination
Eur J Hum Genet. 2016 Feb;24(2):284-90. doi: 10.1038/ejhg.2015.102. Epub 2015 May 27.

Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes.

Author information

1
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
2
Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
3
Pathwest Laboratory Medicine WA, Nedlands, Australia.
4
School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia.
5
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
6
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
7
Department of Medicine, Human Genetics, McGill University, Montreal, Canada.
8
Lady Davis Institute, McGill University, Montreal, Canada.
9
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, UK.

Abstract

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified only a small number of loci associated with sex hormone levels, with several reproductive hormones yet to be assessed. The aim of the study was to identify novel genetic variants contributing to the regulation of sex hormones. We performed GWAS using genotypes imputed from the 1000 Genomes reference panel. The study used genotype and phenotype data from a UK twin register. We included 2913 individuals (up to 294 males) from the Twins UK study, excluding individuals receiving hormone treatment. Phenotypes were standardised for age, sex, BMI, stage of menstrual cycle and menopausal status. We tested 7,879,351 autosomal SNPs for association with levels of dehydroepiandrosterone sulphate (DHEAS), oestradiol, free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone, sex hormone-binding globulin and testosterone. Eight independent genetic variants reached genome-wide significance (P<5 × 10(-8)), with minor allele frequencies of 1.3-23.9%. Novel signals included variants for progesterone (P=7.68 × 10(-12)), oestradiol (P=1.63 × 10(-8)) and FAI (P=1.50 × 10(-8)). A genetic variant near the FSHB gene was identified which influenced both FSH (P=1.74 × 10(-8)) and LH (P=3.94 × 10(-9)) levels. A separate locus on chromosome 7 was associated with both DHEAS (P=1.82 × 10(-14)) and progesterone (P=6.09 × 10(-14)). This study highlights loci that are relevant to reproductive function and suggests overlap in the genetic basis of hormone regulation.

PMID:
26014426
PMCID:
PMC4564946
DOI:
10.1038/ejhg.2015.102
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center