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Twin Res Hum Genet. 2015 Aug;18(4):348-60. doi: 10.1017/thg.2015.29. Epub 2015 May 27.

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.

Silventoinen K1, Jelenkovic A1, Sund R1, Honda C2, Aaltonen S1, Yokoyama Y3, Tarnoki AD4, Tarnoki DL4, Ning F5, Ji F5, Pang Z5, Ordoñana JR6, Sánchez-Romera JF7, Colodro-Conde L6, Burt SA8, Klump KL8, Medland SE9, Montgomery GW9, Kandler C10, McAdams TA11, Eley TC11, Gregory AM12, Saudino KJ13, Dubois L14, Boivin M15, Haworth CM16, Plomin R11, Öncel SY17, Aliev F18, Stazi MA19, Fagnani C19, D'Ippolito C19, Craig JM20, Saffery R20, Siribaddana SH21, Hotopf M22, Sumathipala A21, Spector T23, Mangino M23, Lachance G23, Gatz M24, Butler DA25, Bayasgalan G26, Narandalai D26, Freitas DL27, Maia JA28, Harden KP29, Tucker-Drob EM29, Christensen K30, Skytthe A30, Kyvik KO31, Hong C32, Chong Y32, Derom CA33, Vlietinck RF33, Loos RJ34, Cozen W35, Hwang AE35, Mack TM35, He M36, Ding X36, Chang B36, Silberg JL37, Eaves LJ37, Maes HH38, Cutler TL39, Hopper JL39, Aujard K40, Magnusson PK41, Pedersen NL41, Aslan AK41, Song YM42, Yang S43, Lee K44, Baker LA24, Tuvblad C24, Bjerregaard-Andersen M45, Beck-Nielsen H46, Sodemann M47, Heikkilä K48, Tan Q49, Zhang D50, Swan GE51, Krasnow R52, Jang KL53, Knafo-Noam A54, Mankuta D55, Abramson L54, Lichtenstein P41, Krueger RF56, McGue M56, Pahlen S56, Tynelius P57, Duncan GE58, Buchwald D58, Corley RP59, Huibregtse BM59, Nelson TL60, Whitfield KE61, Franz CE62, Kremen WS62, Lyons MJ63, Ooki S64, Brandt I65, Nilsen TS65, Inui F2, Watanabe M2, Bartels M66, van Beijsterveldt TC66, Wardle J67, Llewellyn CH67, Fisher A67, Rebato E68, Martin NG9, Iwatani Y2, Hayakawa K2, Rasmussen F57, Sung J43, Harris JR65, Willemsen G66, Busjahn A69, Goldberg JH70, Boomsma DI66, Hur YM71, Sørensen TI72, Kaprio J48.

Author information

1
Department of Social Research,University of Helsinki,Helsinki,Finland.
2
Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan.
3
Department of Public Health Nursing,Osaka City University,Osaka,Japan.
4
Department of Radiology and Oncotherapy,Semmelweis University,Budapest,Hungary.
5
Department of Noncommunicable Diseases Prevention,Qingdao Centers for Disease Control and Prevention,Qingdao,China.
6
Department of Human Anatomy and Psychobiology,University of Murcia,Murcia,Spain.
7
IMIB-Arrixaca,Murcia,Spain.
8
Michigan State University,East Lansing,MI,USA.
9
QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
10
Department of Psychology,Bielefeld University,Bielefeld,Germany.
11
MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK.
12
Department of Psychology,Goldsmiths,University of London,London,UK.
13
Department of Psychological and Brain Sciences,Boston University,Boston,MA,USA.
14
School of Epidemiology,Public Health and Preventive Medicine,University of Ottawa,Ottawa,Ontario,Canada.
15
École de psychologie,Université Laval,Québec,Canada.
16
Department of Psychology,University of Warwick Coventry,Coventry,UK.
17
Department of Statistics,Faculty of Arts and Sciences,Kırıkkale University,Kırıkkale,Turkey.
18
Departments of Psychiatry,Psychology,and Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
19
Istituto Superiore di Sanità -- National Center for Epidemiology,Surveillance and Health Promotion,Rome,Italy.
20
Murdoch Childrens Research Institute,Royal Children's Hospital,Melbourne,Victoria,Australia.
21
Institute of Research & Development,Battaramulla,Sri Lanka.
22
NIHR Mental Health Biomedical Research Centre,South London and Maudsley NHS Foundation Trust and,Institute of Psychiatry Psychology and Neuroscience,King's College London,London,UK.
23
Department of Twin Research and Genetic epidemiology,King's College,London,UK.
24
Department of Psychology,University of Southern California,Los Angeles,CA,USA.
25
Institute of Medicine,National Academy of Sciences,Washington,DC,USA.
26
Healthy Twin Association of Mongolia,Ulaanbaatar,Mongolia.
27
Department of Physical Education and Sport,University of Madeira,Funchal,Portugal.
28
CIFI2D,Faculty of Sport,University of Porto,Porto,Portugal.
29
Department of Psychology,University of Texas at Austin,Austin,TX,USA.
30
The Danish Twin Registry,Institute of Public Health,Epidemiology,Biostatistics & Biodemography,University of Southern Denmark,Odense,Denmark.
31
Department of Clinical Research,University of Southern Denmark,Odense,Denmark.
32
Department of Psychology,Pusan National University,Busan,South Korea.
33
Centre of Human Genetics,University Hospitals Leuven,Leuven,Belgium.
34
The Charles Bronfman Institute for Personalized Medicine,The Mindich Child Health and Development Institute,Icahn School of Medicine at Mount Sinai,New York,NY,USA.
35
Department of Preventive Medicine,Keck School of Medicine of USC,University of Southern California,Los Angeles,CA,USA.
36
State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou,China.
37
Department of Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
38
Department of Human and Molecular Genetics,Psychiatry & Massey Cancer Center,Virginia Commonwealth University,Richmond,VA,USA.
39
The Australian Twin Registry,Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia.
40
Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia.
41
Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
42
Department of Family Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea.
43
Department of Epidemiology,School of Public Health,Seoul National University,Seoul,South Korea.
44
Department of Family Medicine,Busan Paik Hospital,Inje University College of Medicine,Busan,South Korea.
45
Bandim Health Project,INDEPTH Network,Apartado,Bissau Codex,Guinea-Bissau.
46
Department of Endocrinology,Odense University Hospital,Odense,Denmark.
47
Department of Infectious Diseases,Odense University Hospital,Odense,Denmark.
48
Department of Public Health,University of Helsinki,Helsinki,Finland.
49
Epidemiology,Biostatistics and Biodemography,Institute of Public Health,University of Southern Denmark,Odense,Denmark.
50
Department of Public Health,Qingdao University Medical College,Qingdao,China.
51
Stanford Prevention Research Center,Department of Medicine,Stanford University School of Medicine,Stanford,CA,USA.
52
Center for Health Sciences,SRI International,Menlo Park,CA,USA.
53
Department of Psychiatry,University of British Columbia,Vancouver,British Columbia,Canada.
54
The Hebrew University of Jerusalem,Jerusalem,Israel.
55
Hadassah Hospital Obstetrics and Gynecology Department,Hebrew University Medical School,Jerusalem,Israel.
56
Department of Psychology,University of Minnesota,Minneapolis,MN,USA.
57
Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.
58
Center for Clinical and Epidemiological Research,University of Washington,Seattle,WA,USA.
59
Institute for Behavioral Genetics,Boulder,CO,USA.
60
Department of Health and Exercise Sciences and Colorado School of Public Health,Colorado State University,Fort Collins,CO,USA.
61
Psychology and Neuroscience,Duke University,Durham,NC,USA.
62
Department of Psychiatry,University of California,San Diego,CA,USA.
63
Boston University,Department of Psychology,Boston,MA,USA.
64
Department of Health Science,Ishikawa Prefectural Nursing University,Kahoku,Ishikawa,Japan.
65
Norwegian Institute of Public Health,Division of Epidemiology,Department of Genes and Environment,Oslo,Norway.
66
Department of Biological Psychology,VU University Amsterdam,Amsterdam,Netherlands.
67
Health Behaviour Research Centre,Department of Epidemiology and Public Health,Institute of Epidemiology and Health Care,University College London,London,UK.
68
Department of Genetics,Physical Anthropology and Animal Physiology,University of the Basque Country UPV/EHU,Leioa,Spain.
69
HealthTwiSt GmbH,Berlin,Germany.
70
Department of Epidemiology,School of Public Health,University of Washington,Seattle,WA,USA.
71
Department of Education,Mokpo National University,Jeonnam,South Korea.
72
Novo Nordisk Foundation Centre for Basic Metabolic Research,Section on Metabolic Genetics,Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark.

Abstract

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

KEYWORDS:

BMI; height; heritability; international comparisons; twins

PMID:
26014041
PMCID:
PMC4696543
DOI:
10.1017/thg.2015.29
[Indexed for MEDLINE]
Free PMC Article

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