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Epilepsia. 2015 Jul;56(7):e95-8. doi: 10.1111/epi.13038. Epub 2015 May 23.

Ketogenic diet exhibits anti-inflammatory properties.

Author information

1
INSERM, U1141, Paris, France.
2
INSERM UMR1141, Paris Diderot University, Paris, France.
3
AP-HP, Biochemistery Department, Robert Debre Univeristy Hospital, Paris, France.
4
AP-HP, Pediatric Neurology Department, Robert Debre University Hospital, Paris, France.

Abstract

The ketogenic diet (KD) is an established treatment for refractory epilepsy, including some inflammation-induced epileptic encephalopathies. In a lipopolysaccharide (LPS)-induced fever model in rats, we found that animals given the KD for 14 days showed less fever and lower proinflammatory cytokine levels than control animals. However, KD rats exhibited a decrease in circulating levels of arachidonic acid and long-chain n-3 polyunsaturated fatty acids (PUFAs), suggesting that the anti-inflammatory effect of KD was probably not due to an increase in anti-inflammatory n-3 PUFA derivatives. These properties might be of interest in some conditions such as fever-induced refractory epileptic encephalopathy in school-aged children.

KEYWORDS:

Epilepsy; FIRES; IL-1β; Ketogenic diet; Polyunsaturated fatty acids

PMID:
26011473
DOI:
10.1111/epi.13038
[Indexed for MEDLINE]
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