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Philos Trans R Soc Lond B Biol Sci. 2015 Jul 5;370(1672). pii: 20140182. doi: 10.1098/rstb.2014.0182.

Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin.

Author information

1
Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK mike.ludwig@ed.ac.uk.
2
Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.

Abstract

The mammalian hypothalamic magnocellular neurons of the supraoptic and paraventricular nuclei are among the best understood of all peptidergic neurons. Through their anatomical features, vasopressin- and oxytocin-containing neurons have revealed many important aspects of dendritic functions. Here, we review our understanding of the mechanisms of somato-dendritic peptide release, and the effects of autocrine, paracrine and hormone-like signalling on neuronal networks and behaviour.

KEYWORDS:

calcium; homeostasis; hypothalamus; paraventricular nucleus; priming; supraoptic nucleus

PMID:
26009761
PMCID:
PMC4455751
DOI:
10.1098/rstb.2014.0182
[Indexed for MEDLINE]
Free PMC Article

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