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Biochem Soc Trans. 2015 Jun;43(3):508-12. doi: 10.1042/BST20150059.

Gap junctions - guards of excitability.

Author information

1
*Department of Biomedical Sciences and The Danish National Research Foundation Centre for Cardiac Arrhythmia, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
2
†Department of Biomedical Sciences and Core Facility for Integrated Microscopy, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
3
‡Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, U.S.A.

Abstract

Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

PMID:
26009199
DOI:
10.1042/BST20150059
[Indexed for MEDLINE]

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