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J Cell Biol. 2015 May 25;209(4):485-91. doi: 10.1083/jcb.201502016.

The expanding implications of polyploidy.

Author information

1
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710.
2
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710 don.fox@duke.edu.

Abstract

Polyploid cells, which contain more than two genome copies, occur throughout nature. Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also promote nonuniform genome, transcriptome, and metabolome alterations. Polyploidy also frequently confers resistance to environmental stresses not tolerated by diploid cells. Recent progress has begun to unravel how this fascinating phenomenon contributes to normal physiology and disease.

PMID:
26008741
PMCID:
PMC4442802
DOI:
10.1083/jcb.201502016
[Indexed for MEDLINE]
Free PMC Article

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