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Nat Neurosci. 2015 Jul;18(7):956-8. doi: 10.1038/nn.4026. Epub 2015 May 25.

Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.

Author information

1
Institute of Neuroscience CNR, Pisa, Italy.
2
1] Institute of Neuroscience CNR, Pisa, Italy. [2] BioSNS, Scuola Normale Superiore di Pisa, Pisa, Italy.
3
1] Institute of Genetics and Biophysics "A. Buzzati Traverso" CNR via P. Castellino, Napoli, Italy. [2] IRCCS INM Neuromed, Pozzilli, IS, Italy.
4
1] Institute of Neuroscience CNR, Pisa, Italy. [2] Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Firenze, Italy.

Abstract

DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program.

PMID:
26005848
DOI:
10.1038/nn.4026
[Indexed for MEDLINE]

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