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Aging Male. 2015;18(3):175-9. doi: 10.3109/13685538.2015.1034686. Epub 2015 May 25.

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men.

Author information

1
a Department of Pharmacology and.
2
b Department of Biochemistry, Faculty of Medicine , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.

Abstract

OBJECTIVE:

Cross-sectional studies in the Caucasian population have shown a significant relationship between vitamin D and testosterone levels, but data in the Asian population are limited. This study aimed to determine the association between vitamin D and testosterone levels in Malaysian men.

METHODS:

Chinese and Malay men (n = 382) aged 20 years or above residing in the Klang Valley, Malaysia were recruited. Their fasting blood was collected for serum testosterone, sex hormone-binding globulin (SHBG) and 25-hydroxyvitamin D (25(OH)D) assays. Relationship between 25(OH)D and testosterone levels was analyzed using multiple regression analysis. Testosterone and SHBG levels among subjects with different vitamin D status were compared using univariate analysis. Confounders such as age, ethnicity and body mass index (BMI) were adjusted.

RESULTS:

25(OH)D was significantly and positively associated with total testosterone and SHBG levels before and after adjustment for age and ethnicity (p < 0.05). Only association with SHBG remained significant after further adjustment for BMI (p < 0.05). Total testosterone and SHBG values displayed an increasing trend from subjects with vitamin D deficiency to those with optimal level (p < 0.05). The trend was attenuated after adjustment for BMI (p > 0.05).

CONCLUSION:

25(OH)D is significantly associated with total testosterone and SHBG in Malaysian men but this association is BMI-dependent.

KEYWORDS:

Men; sex hormone-binding globulin; testosterone; vitamin D

PMID:
26004987
DOI:
10.3109/13685538.2015.1034686
[Indexed for MEDLINE]

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