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Aging Male. 2015;18(3):175-9. doi: 10.3109/13685538.2015.1034686. Epub 2015 May 25.

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men.

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a Department of Pharmacology and.
b Department of Biochemistry, Faculty of Medicine , Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.



Cross-sectional studies in the Caucasian population have shown a significant relationship between vitamin D and testosterone levels, but data in the Asian population are limited. This study aimed to determine the association between vitamin D and testosterone levels in Malaysian men.


Chinese and Malay men (n = 382) aged 20 years or above residing in the Klang Valley, Malaysia were recruited. Their fasting blood was collected for serum testosterone, sex hormone-binding globulin (SHBG) and 25-hydroxyvitamin D (25(OH)D) assays. Relationship between 25(OH)D and testosterone levels was analyzed using multiple regression analysis. Testosterone and SHBG levels among subjects with different vitamin D status were compared using univariate analysis. Confounders such as age, ethnicity and body mass index (BMI) were adjusted.


25(OH)D was significantly and positively associated with total testosterone and SHBG levels before and after adjustment for age and ethnicity (p < 0.05). Only association with SHBG remained significant after further adjustment for BMI (p < 0.05). Total testosterone and SHBG values displayed an increasing trend from subjects with vitamin D deficiency to those with optimal level (p < 0.05). The trend was attenuated after adjustment for BMI (p > 0.05).


25(OH)D is significantly associated with total testosterone and SHBG in Malaysian men but this association is BMI-dependent.


Men; sex hormone-binding globulin; testosterone; vitamin D

[Indexed for MEDLINE]

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