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Int J Neurosci. 2016;126(7):630-6. doi: 10.3109/00207454.2015.1051046. Epub 2015 Aug 18.

Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment.

Author information

1
a 1 Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
2
b 2 Department of Neurosurgery , Nanjing Children's Hospital of Nanjing Medical University , Nanjing , China.

Abstract

PURPOSE:

This study aimed to evaluate the level of taurine in plasma, and its association with the severity of motor and non-motor symptoms (NMS) and chronic levodopa treatment in Parkinson's disease (PD).

PATIENTS AND METHODS:

Plasma taurine level was measured in treated PD (tPD), untreated PD (ntPD) and control groups. Motor symptoms and NMS were assessed using the Unified Parkinson's Disease Rating Scale, the short form of the McGill Pain Questionnaire, the Hamilton Depression Scale, the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms and the Pittsburgh Sleep Quality Index. Longtime exposure to levodopa was indicated by its approximate cumulative dosage.

RESULTS:

The plasma taurine levels of PD patients were decreased when compared with controls and negatively associated with motor severity but not NMS. Moreover, tPD patients exhibited lower levels of plasma taurine than ntPD patients. Interestingly, plasma taurine levels negatively correlated with cumulative levodopa dosage in tPD. After controlling for potential confounders, the association between taurine and levodopa remained significant.

CONCLUSION:

Our study supports that taurine may play important roles in the pathophysiology of PD and the disturbances caused by chronic levodopa administration.

KEYWORDS:

Parkinson's disease; levodopa; motor severity; taurine

PMID:
26004911
DOI:
10.3109/00207454.2015.1051046
[Indexed for MEDLINE]

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