Send to

Choose Destination
J Trace Elem Med Biol. 2015;31:120-8. doi: 10.1016/j.jtemb.2015.03.008. Epub 2015 Apr 22.

Encapsulated boron as an osteoinductive agent for bone scaffolds.

Author information

Hacettepe University, Department of Bioengineering, Ankara, Turkey. Electronic address:
Hacettepe University, Department of Bioengineering, Ankara, Turkey.
Bülent Ecevit University, Department of Biomedical Engineering, Zonguldak, Turkey.
Selcuk University, Faculty of Dentistry, Department of Periodontology, Konya, Turkey.


The aim of this study was to develop boron (B)-releasing polymeric scaffold to promote regeneration of bone tissue. Boric acid-doped chitosan nanoparticles with a diameter of approx. 175 nm were produced by tripolyphosphate (TPP)-initiated ionic gelation process. The nanoparticles strongly attached via electrostatic interactions into chitosan scaffolds produced by freeze-drying with approx. 100 μm pore diameter. According to the ICP-OES results, following first 5h initial burst release, fast release of B from scaffolds was observed for 24h incubation period in conditioned medium. Then, slow release of B was performed over 120 h. The results of the cell culture studies proved that the encapsulated boron within the scaffolds can be used as an osteoinductive agent by showing its positive effects on the proliferation and differentiation of MC3T3-E1 preosteoblastic cells.


Bone tissue engineering; Boron; Chitosan; Nanoparticle; Scaffold

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center