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Clin Lab Med. 2015 Jun;35(2):333-44. doi: 10.1016/j.cll.2015.02.001. Epub 2015 Mar 18.

Markers of intestinal inflammation for the diagnosis of infectious gastroenteritis.

Author information

1
Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, Washington University in St. Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA.
2
Department of Pathology and Immunology, Washington University School of Medicine, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
3
Department of Pathology and Immunology, Washington University School of Medicine, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: cburnham@path.wustl.edu.

Abstract

Infectious diarrhea is a major cause of morbidity. A rapid and inexpensive assay for the diagnosis of infectious gastroenteritis would expedite appropriate therapy and prevent unnecessary and potentially invasive testing. This article summarizes assays for the diagnosis of infectious gastroenteritis based on the host response to bacterial, viral, or parasitic infection. This includes both systemic biomarkers (such as C-reactive protein, erythrocyte sedimentation rate, and serum cytokines) and fecal biomarkers (such as lactoferrin, fecal leukocyte analysis, and calprotectin). Although some of these assays have value as adjunct diagnostics, they lack sensitivity and specificity as stand-alone tests in this setting.

KEYWORDS:

Biomarker; C-reactive protein; Erythrocyte sedimentation reaction; Fecal leukocyte; IFN-γ; IL-6; IL-8; TNF-α

PMID:
26004646
DOI:
10.1016/j.cll.2015.02.001
[Indexed for MEDLINE]

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