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Curr Opin Genet Dev. 2015 Apr;31:57-66. doi: 10.1016/j.gde.2015.04.002. Epub 2015 May 22.

X-chromosome inactivation: new insights into cis and trans regulation.

Author information

1
Mammalian Developmental Epigenetics Group, Institut Curie, PSL University, CNRS UMR3215, INSERM U934, 26, rue d'Ulm, 75005 Paris, France.
2
Mammalian Developmental Epigenetics Group, Institut Curie, PSL University, CNRS UMR3215, INSERM U934, 26, rue d'Ulm, 75005 Paris, France. Electronic address: edith.heard@curie.fr.

Abstract

X-chromosome inactivation (XCI) is a developmentally associated process that evolved in mammals to enable gene dosage compensation between XX and XY individuals. In placental mammals, it is triggered by the long noncoding RNA Xist, which is produced from a complex regulatory locus, the X-inactivation centre (Xic). Recent insights into the regulatory landscape of the Xic, including its partitioning into topological associating domains (TADs) and its genetic dissection, have important implications for the monoallelic regulation of Xist. Here, we present some of the latest studies on X inactivation with a special focus on the regulation of Xist, its various functions and the putative role of chromosome conformation in regulating the dynamics of this locus during development and differentiation.

PMID:
26004255
DOI:
10.1016/j.gde.2015.04.002
[Indexed for MEDLINE]

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