Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis

J Neuroimmunol. 2015 Jun 15:283:64-9. doi: 10.1016/j.jneuroim.2015.04.011. Epub 2015 Apr 25.

Abstract

Cerebrospinal fluid (CSF) CXCL13 was shown to correlate with markers of intrathecal inflammation and CSF oligoclonal IgM bands (IgMOB) have been associated with a more severe Multiple Sclerosis (MS) course. We correlated CSF CXCL13 levels with clinical, MRI and CSF parameters, including CSF IgMOB, in 110 Clinically Isolated Syndrome (CIS) patients. CSF CXCL13 levels correlated with CSF cell count, total protein, IgG Index and with the presence of CSF IgGOB and IgMOB. CSF CXCL13 levels ≥15.4 pg/ml showed a good positive predictive value and specificity for a MS diagnosis and for a clinical relapse within one year from onset.

Keywords: CXCL13; Cerebrospinal fluid; Clinically Isolated Syndrome; IgM oligoclonal bands; Multiple Sclerosis; Relapsing–remitting.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Brain / pathology
  • Chemokine CXCL13 / blood
  • Chemokine CXCL13 / cerebrospinal fluid*
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / immunology
  • Oligoclonal Bands / blood
  • Oligoclonal Bands / cerebrospinal fluid*
  • Predictive Value of Tests
  • Recurrence
  • Risk Factors
  • Spinal Cord / pathology
  • Young Adult

Substances

  • CXCL13 protein, human
  • Chemokine CXCL13
  • Oligoclonal Bands