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J Neuroimmunol. 2015 Jun 15;283:50-7. doi: 10.1016/j.jneuroim.2015.04.014. Epub 2015 Apr 25.

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease.

Author information

1
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: erdincdu@yahoo.com.
2
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: duygugezenak@gmail.com.
3
Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
4
Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
5
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
6
Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
7
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: drselmayilmazer@gmail.com.

Abstract

Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA. IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls. A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.

KEYWORDS:

Alpha-2 macroglobulin (α2-macroglobulin); Alzheimer's disease; Biomarker; Brain derived neurotrophic factor (BDNF); Heat shock protein 90 (Hsp90); Interleukin 1 alpha (IL-1α); Interleukin 1 beta (IL-1β); Interleukin 10 (IL-10); Interleukin 6 (IL-6); Mild cognitive impairment (MCI); Parkinson's disease (PD); Tumor necrosis factor alpha (TNFα)

PMID:
26004156
DOI:
10.1016/j.jneuroim.2015.04.014
[Indexed for MEDLINE]

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