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Gynecol Obstet Fertil. 2015 Jun;43(6):437-42. doi: 10.1016/j.gyobfe.2015.04.008. Epub 2015 May 21.

[Efficacy of a medical device containing liposomal hyaluronic acid against vulvo-vaginal dryness].

[Article in French]

Author information

1
Institut Alfred-Fournier, 25, boulevard Saint-Jacques, 75014 Paris, France.
2
Iprad Pharma, 174, quai de Jemmapes, 75010 Paris, France. Electronic address: g.brami@iprad-labo.com.
3
Service de gynécologie-obstétrique, CHRU de Nîmes, place du Professeur-Robert-Debré, 30029 Nîmes, France.

Abstract

OBJECTIVES:

Hyaluronic acid (HA) is present in the vulval and vaginal conjonctive tissue. It possesses hydrating and healing properties and is indicated to treat menopause induced vulvo-vaginal atrophy. The goal of this study is to evaluate the efficacy of a medical device containing liposomal HA upon patients of different ages suffering from vulvo-vaginal dryness (VVD).

METHODS:

Tested product Mucogyne® was applied 3 times a week for 84 days by 47 patients, 28 premenopausal young women (mean age: 32 years old) and 19 post-menopausal women (mean age: 57.5 years old) all suffering from VVD associated to spontaneous pain and dyspareunia. Clinical evaluations and Vaginal Health Index (VHS) were calculated at 0, 1 and 3 months.

RESULTS:

A significant clinical improvement (P<0.001) occurred at 1 month (-25 % for dryness and -46 % for pain) and at 3 months (respectively -86 and -79 %). VHS was significantly improved (P<0.001) from 30 % at 1 month to 72 % after 3 months.

CONCLUSION:

Liposomal AH significantly decreases symptoms and clinical signs of VVD at all ages and represents a safe and efficient alternative to topical and/or systemic hormonal therapy after menopause.

KEYWORDS:

Acide hyaluronique liposomé; Atrophie vulvo-vaginale; Hyaluronic acid; Liposomal; Mucogyne(®); Sécheresse vulvo-vaginale; Vulvo-vaginal atrophy; Vulvo-vaginal dryness

PMID:
26004026
DOI:
10.1016/j.gyobfe.2015.04.008
[Indexed for MEDLINE]

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