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Cancer Lett. 2015 Aug 28;365(1):107-11. doi: 10.1016/j.canlet.2015.05.013. Epub 2015 May 19.

Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma.

Author information

1
Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, 3 Avenue Hubert Curien BP13562, 31035 Toulouse Cedex 1, France.
2
Centre Hospitalier Universitaire de Toulouse, F-31300 France.
3
Centre Hospitalier Universitaire de Toulouse, F-31300 France; Centre de Recherche en Cancérologie de Toulouse, Unité Mixte de Recherche 1037 INSERM - Université Toulouse III, France.
4
Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, 3 Avenue Hubert Curien BP13562, 31035 Toulouse Cedex 1, France. Electronic address: anna.kruczynski@pierre-fabre.com.

Abstract

Chromosomal rearrangements of the NTRK1 gene, which encodes the high affinity nerve growth factor receptor (tropomyosin related kinase, TRKA), have been observed in several epithelial cancers, such as colon cancer, papillary thyroid carcinoma or non small cell lung cancer. The various NTRK1 fusions described so far lead to constitutive activation of TRKA kinase activity and are oncogenic. We further investigated here the existence and the frequency of NTRK1 gene rearrangements in colorectal cancer. Using immunohistochemistry and quantitative reverse transcriptase PCR, we analyzed a series of human colorectal cancers. We identified two TRKA positive cases over 408, with NTRK1 chromosomal rearrangements. One of these rearrangements is a TPM3-NTRK1 fusion already observed in colon cancer, while the second one is a TPR-NTRK1 fusion never described in this type of cancer. These findings further confirm that translocations in the NTRK1 gene are recurring events in colorectal cancer, although occurring at a low frequency (around 0.5%).

KEYWORDS:

Colon cancer; Gene rearrangement; NTRK1; TRKA

PMID:
26001971
DOI:
10.1016/j.canlet.2015.05.013
[Indexed for MEDLINE]

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