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Immunobiology. 2016 Jun;221(6):719-25. doi: 10.1016/j.imbio.2015.05.001. Epub 2015 May 11.

The paradoxical roles of C1q and C3 in autoimmunity.

Author information

1
Centre for Complement and Inflammation Research, Department of Medicine, Imperial College London, London, UK.
2
Centre for Complement and Inflammation Research, Department of Medicine, Imperial College London, London, UK. Electronic address: m.botto@imperial.ac.uk.

Abstract

In this review we will focus on the links between complement and autoimmune diseases and will highlight how animal models have provided insights into the manner by which C1q and C3 act to modulate both adaptive and innate immune responses. In particular we will highlight how C1q may not only act as initiator of the classical complement pathway, but can also mediate multiple immune responses in a complement activation independent manner.

KEYWORDS:

Autoimmunity; Complement; Systemic lupus erythematosus; Tolerance

PMID:
26001732
DOI:
10.1016/j.imbio.2015.05.001
[Indexed for MEDLINE]
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