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Trends Immunol. 2015 Jun;36(6):364-73. doi: 10.1016/j.it.2015.04.007. Epub 2015 May 20.

The choreography of neuroinflammation in Huntington's disease.

Author information

1
Biogen, Cambridge, MA, USA.
2
Department of Cellular and Molecular Medicine, University of California San Diego, CA, USA; Department of Medicine, University of California San Diego, CA, USA. Electronic address: ckg@ucsd.edu.

Abstract

Currently, the concept of 'neuroinflammation' includes inflammation associated with neurodegenerative diseases, in which there is little or no infiltration of blood-derived immune cells into the brain. The roles of brain-resident and peripheral immune cells in these inflammatory settings are poorly understood, and it is unclear whether neuroinflammation results from immune reaction to neuronal dysfunction/degeneration, and/or represents cell-autonomous phenotypes of dysfunctional immune cells. Here, we review recent studies examining these questions in the context of Huntington's disease (HD), where mutant Huntingtin (HTT) is expressed in both neurons and glia. Insights into the cellular and molecular mechanisms underlying neuroinflammation in HD may provide a better understanding of inflammation in more complex neurodegenerative disorders, and of the contribution of the neuroinflammatory component to neurodegenerative disease pathogenesis.

KEYWORDS:

Huntington's disease; astrocytes; macrophages; microglia; neuroinflammation

PMID:
26001312
PMCID:
PMC4786070
DOI:
10.1016/j.it.2015.04.007
[Indexed for MEDLINE]
Free PMC Article

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