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Curr Opin Cell Biol. 2015 Aug;35:69-77. doi: 10.1016/j.ceb.2015.04.013. Epub 2015 May 19.

Extracellular vesicles shuffling intercellular messages: for good or for bad.

Author information

1
Institut Curie, PSL Research University, F-75248 Paris, France; Centre National de la Recherche Scientifique, UMR144, Structure and Membrane Compartments, Paris F-75248, France.
2
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
3
Institut Curie, PSL Research University, F-75248 Paris, France; Centre National de la Recherche Scientifique, UMR144, Structure and Membrane Compartments, Paris F-75248, France. Electronic address: graca.raposo@curie.fr.

Abstract

The release of extracellular vesicles (EVs) is a highly conserved process exploited by diverse organisms as a mode of intercellular communication. Vesicles of sizes ranging from 30 to 1000nm, or even larger, are generated by blebbing of the plasma membrane (microvesicles) or formed in multivesicular endosomes (MVEs) to be secreted by exocytosis as exosomes. Exosomes, microvesicles and other EVs contain membrane and cytosolic components that include proteins, lipids and RNAs, a composition that differs related to their site of biogenesis. Several mechanisms are involved in vesicle formation at the plasma membrane or in endosomes, which is reflected in their heterogeneity, size and composition. EVs have significant promise for therapeutics and diagnostics and for understanding physiological and pathological processes all of which have boosted research to find modulators of their composition, secretion and targeting.

PMID:
26001269
DOI:
10.1016/j.ceb.2015.04.013
[Indexed for MEDLINE]

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