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Mol Cell. 2015 May 21;58(4):598-609. doi: 10.1016/j.molcel.2015.05.005.

Advances and applications of single-cell sequencing technologies.

Author information

1
Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
2
Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: nnavin@mdanderson.org.

Abstract

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for studying rare cells and delineating complex populations. Over the past 5 years, SCS methods for DNA and RNA have had a broad impact on many diverse fields of biology, including microbiology, neurobiology, development, tissue mosaicism, immunology, and cancer research. In this review, we will discuss SCS technologies and applications, as well as translational applications in the clinic.

PMID:
26000845
PMCID:
PMC4441954
DOI:
10.1016/j.molcel.2015.05.005
[Indexed for MEDLINE]
Free PMC Article

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