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Int J Neurosci. 2016;126(5):393-9. doi: 10.3109/00207454.2015.1025395. Epub 2015 Aug 11.

Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis.

Author information

1
a Department of Neurology , Chinese PLA General Hospital , Beijing , China and.
2
b Department of Endocrine , Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA , Lanzhou , China.

Abstract

BACKGROUND:

Many studies investigated the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and migraine, with controversial results. Thus, we performed a meta-analysis to better evaluate the correlation of this polymorphism and migraine.

METHODS:

We retrieved studies published up to September 2014 about the ACE gene polymorphism and migraine from electronic database. Pooled odds ratios (ORs) with 95% confidence interval (CI) were calculated to examine the strength of association between the ACE I/D polymorphism and migraine, using random-effects models.

RESULTS:

We identified 14 separate studies, in which 7334 migraineurs and 22 990 healthy controls were eligible for the meta-analysis. The results showed no relationship between the ACE I/D polymorphism and any migraine. Stratification revealed a protective effect in the Turkish population against migraine with aura for the II genotype model (II vs. DD: pooled OR = 0.366, 95% CI = 0.137-0.980; II vs. DI + DD: pooled OR = 0.370, 95% CI = 0.145-0.945). Similar results were obtained for Turkish people with migraine without aura (II vs. DD: pooled OR = 0.386; 95% CI = 0.166-0.900; II vs. DI + DD: pooled OR = 0.347; 95% CI = 0.156-0.773).

CONCLUSIONS:

The data suggest that the ACE II genotype could exert a protective effect against migraine with aura and without aura at least in the Turkish population.

KEYWORDS:

angiotensin-converting enzyme; insertion/deletion polymorphism; meta-analysis; migraine disorders; migraine with aura; migraine without aura

PMID:
26000817
DOI:
10.3109/00207454.2015.1025395
[Indexed for MEDLINE]

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