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Int J Neurosci. 2016;126(5):393-9. doi: 10.3109/00207454.2015.1025395. Epub 2015 Aug 11.

Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis.

Author information

a Department of Neurology , Chinese PLA General Hospital , Beijing , China and.
b Department of Endocrine , Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA , Lanzhou , China.



Many studies investigated the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and migraine, with controversial results. Thus, we performed a meta-analysis to better evaluate the correlation of this polymorphism and migraine.


We retrieved studies published up to September 2014 about the ACE gene polymorphism and migraine from electronic database. Pooled odds ratios (ORs) with 95% confidence interval (CI) were calculated to examine the strength of association between the ACE I/D polymorphism and migraine, using random-effects models.


We identified 14 separate studies, in which 7334 migraineurs and 22 990 healthy controls were eligible for the meta-analysis. The results showed no relationship between the ACE I/D polymorphism and any migraine. Stratification revealed a protective effect in the Turkish population against migraine with aura for the II genotype model (II vs. DD: pooled OR = 0.366, 95% CI = 0.137-0.980; II vs. DI + DD: pooled OR = 0.370, 95% CI = 0.145-0.945). Similar results were obtained for Turkish people with migraine without aura (II vs. DD: pooled OR = 0.386; 95% CI = 0.166-0.900; II vs. DI + DD: pooled OR = 0.347; 95% CI = 0.156-0.773).


The data suggest that the ACE II genotype could exert a protective effect against migraine with aura and without aura at least in the Turkish population.


angiotensin-converting enzyme; insertion/deletion polymorphism; meta-analysis; migraine disorders; migraine with aura; migraine without aura

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