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Cell. 2015 May 21;161(5):1089-1100. doi: 10.1016/j.cell.2015.04.024.

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors.

Author information

1
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: panagiotis.sarris@tsl.ac.uk.
2
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK.
3
Bio-protection Research Centre, Institute of Agriculture and Environment, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.
4
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: jonathan.jones@tsl.ac.uk.

Abstract

Defense against pathogens in multicellular eukaryotes depends on intracellular immune receptors, yet surveillance by these receptors is poorly understood. Several plant nucleotide-binding, leucine-rich repeat (NB-LRR) immune receptors carry fusions with other protein domains. The Arabidopsis RRS1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS4, another NB-LRR protein. This complex detects the bacterial effectors AvrRps4 or PopP2 and then activates defense. Both bacterial proteins interact with the RRS1 WRKY domain, and PopP2 acetylates lysines to block DNA binding. PopP2 and AvrRps4 interact with other WRKY domain-containing proteins, suggesting these effectors interfere with WRKY transcription factor-dependent defense, and RPS4/RRS1 has integrated a "decoy" domain that enables detection of effectors that target WRKY proteins. We propose that NB-LRR receptor pairs, one member of which carries an additional protein domain, enable perception of pathogen effectors whose function is to target that domain.

PMID:
26000484
DOI:
10.1016/j.cell.2015.04.024
[Indexed for MEDLINE]
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