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Cell. 2015 May 21;161(5):967-970. doi: 10.1016/j.cell.2015.04.045.

Alike but Different: RAF Paralogs and Their Signaling Outputs.

Author information

1
Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria.
2
Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: manuela.baccarini@univie.ac.at.

Abstract

RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.

PMID:
26000477
DOI:
10.1016/j.cell.2015.04.045
[Indexed for MEDLINE]
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