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J Antimicrob Chemother. 1989 Nov;24(5):637-45.

Emergence of methicillin-resistant clones from cephamycin-resistant Staphylococcus aureus.

Author information

1
Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.

Abstract

Staphylococcus aureus strains specifically resistant to cephamycin antibiotics have been found among recent clinical isolates. These strains formed penicillin-binding protein (PBP) 2' and became phenotypically resistant to methicillin after induction with cefoxitin. Other cephamycin-type antibiotics also induced methicillin-resistance, whereas non-cephamycin-type cephalosporins such as cefmenoxime and ceftizoxime did not do so. The clones that constitutively synthesized PBP 2' arose from the cephamycin-resistant strains at a frequency of 10(-5). They were indistinguishable from clinically isolated methicillin-resistant S. aureus (MRSA). Cephamycin-resistant S. aureus may be a source for emerging MRSA.

PMID:
2599989
DOI:
10.1093/jac/24.5.637
[Indexed for MEDLINE]

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