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Circ Res. 2015 May 22;116(11):1783-99. doi: 10.1161/CIRCRESAHA.116.305432.

Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.

Author information

1
From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
2
From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA. mochly@stanford.edu.

Abstract

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

KEYWORDS:

mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species

PMID:
25999419
PMCID:
PMC4443500
DOI:
10.1161/CIRCRESAHA.116.305432
[Indexed for MEDLINE]
Free PMC Article

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