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Anaerobe. 2015 Aug;34:116-9. doi: 10.1016/j.anaerobe.2015.05.003. Epub 2015 May 18.

Occurrence and new mutations involved in rifampicin-resistant Propionibacterium acnes strains isolated from biofilm or device-related infections.

Author information

1
Septic Surgical Unit, Department of Surgery and Anaesthesiology, Lausanne University Hospital, Lausanne, Switzerland.
2
Service de Bactériologie-Hygiène Hospitalière, Nantes University Hospital, Nantes, France; Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, Nantes Medicine School, F-44000 Nantes, France.
3
Infectious Diseases Service, Zurich University Hospital, Zurich, Switzerland.
4
Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, Berlin, Germany.
5
Service de Bactériologie-Hygiène Hospitalière, Nantes University Hospital, Nantes, France; Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, Nantes Medicine School, F-44000 Nantes, France. Electronic address: stephane.corvec@chu-nantes.fr.

Abstract

We described for the first time the amino acid substitutions conferring rifampicin resistance in eight Propionibacterium acnes strains isolated from patients with biofilm or device-related infections. We identified different mutations in cluster I and one mutation, never reported, in cluster II of the rpoB gene (I480V) associated with the most frequent one in cluster I (S442L). Half of the patients previously received treatment with rifampicin.

KEYWORDS:

Biofilm; Foreign-body infection; Propionibacterium acnes; Resistance; Rifampicin

PMID:
25999299
DOI:
10.1016/j.anaerobe.2015.05.003
[Indexed for MEDLINE]

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