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Infect Dis Clin North Am. 2015 Jun;29(2):295-307. doi: 10.1016/j.idc.2015.02.005.

Laboratory diagnosis of Lyme disease: advances and challenges.

Author information

1
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10/12C118 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: amarques@niaid.nih.gov.

Abstract

The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field.

KEYWORDS:

Borrelia burgdorferi; Laboratory diagnosis; Lyme disease; Serology

PMID:
25999225
PMCID:
PMC4441761
DOI:
10.1016/j.idc.2015.02.005
[Indexed for MEDLINE]
Free PMC Article

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