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Neuroimage. 2015 Aug 15;117:327-42. doi: 10.1016/j.neuroimage.2015.05.008. Epub 2015 May 19.

Meta-analytic connectivity and behavioral parcellation of the human cerebellum.

Author information

  • 1Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
  • 2Imaging Research Center, University of California Davis, Sacramento, CA, USA.
  • 3Department of Psychology, Florida International University, Miami, FL, USA.
  • 4Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA.
  • 5Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Dusseldorf, Germany.
  • 6Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA; State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China.
  • 7Department of Physics, Florida International University, Miami, FL, USA. Electronic address: alaird@fiu.edu.

Abstract

The cerebellum historically has been thought to mediate motor and sensory signals between the body and cerebral cortex, yet cerebellar lesions are also associated with altered cognitive behavioral performance. Neuroimaging evidence indicates that the cerebellum contributes to a wide range of cognitive, perceptual, and motor functions. Here, we used the BrainMap database to investigate whole-brainco-activation patterns between cerebellar structures and regions of the cerebral cortex, as well as associations with behavioral tasks. Hierarchical clustering was performed to meta-analytically identify cerebellar structures with similar cortical co-activation, and independently, with similar correlations to specific behavioral tasks. Strong correspondences were observed in these separate but parallel analyses of meta-analytic connectivity and behavioral metadata. We recovered differential zones of cerebellar co-activation that are reflected across the literature. Furthermore, the behaviors and tasks associated with the different cerebellar zones provide insight into the specialized function of the cerebellum, relating to high-order cognition, emotion, perception, interoception, and action. Taken together, these task-basedmeta-analytic results implicate distinct zones of the cerebellum as critically involved in the monitoring and mediation of psychological responses to internal and external stimuli.

KEYWORDS:

BrainMap; Cerebellum; Co-activations; Functional connectivity; MACM; Meta-analysis; Meta-analytic connectivity modeling; Neuroinformatics

PMID:
25998956
PMCID:
PMC4512917
DOI:
10.1016/j.neuroimage.2015.05.008
[PubMed - indexed for MEDLINE]
Free PMC Article
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